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Labeling of Cannabidiol Products: A Public Health Perspective

1 The Center for Medical Cannabis Education, Del Mar, California, USA.

2 Helfgott Research Institute, National University of Natural Medicine (NUNM), Portland, Oregon, USA.

Douglas MacKay

3 Scientific and Regulatory Affairs, CV Sciences, Inc., San Diego, California, USA.

William Dolphin

4 Communications Department, Americans for Safe Access, Washington, District of Columbia, USA.

5 Graduate School of Education and College of Arts and Sciences, University of Redlands, Redlands, California, USA.

2 Helfgott Research Institute, National University of Natural Medicine (NUNM), Portland, Oregon, USA.

5 Graduate School of Education and College of Arts and Sciences, University of Redlands, Redlands, California, USA.

* Address correspondence to: Jamie Corroon, ND, MPH, The Center for Medical Cannabis Education, 428 8th Street, Del Mar, CA 92014, USA [email protected]

Abstract

Introduction: Interest in the therapeutic use of cannabidiol (CBD) has reached a fever-pitch in recent months, as CBD-containing products appear everywhere from online retailers to grocery stores and gas stations. The widespread availability of hemp-derived CBD products is confounding given that CBD is a U.S. Food and Drug Administration (FDA)-approved drug, and thus precluded from being added to food and beverages, or included in dietary supplements. The use by manufacturers of disease-related claims on marketing materials and product labels, along with the federal legalization of hemp in December 2018, has created political pressure on FDA to promulgate regulations.

Conclusions: Accurate and informative labeling of hemp and hemp-derived CBD products is an important public health issue. FDA-regulated product labels are considered an essential tool for protecting consumers and enabling informed decision-making. Untruthful or unsubstantiated health-related claims, and unallowed Drug Claims, in marketing materials and on labels of CBD products may create harm by enticing consumers to forgo more evidence-based medical interventions. Furthermore, missing or inaccurate labeling of the amount of CBD, delta-9 tetrahydrocannabinol (THC), and potentially harmful contaminants such as pesticides, naturally-occurring yeast and mold or heavy metals may result in harm and/or lack of efficacy. Manufacturers of these products may reasonably be expected to understand and adhere to FDA regulations for labeling and marketing of food, dietary supplements and drugs, both over-the-counter (OTC) and prescription, even though FDA has interpreted federal law as excluding them from these categories. As manufacturers prepare for forthcoming regulations, a better understanding of the basic framework for FDA labeling and marketing regulations for food, dietary supplements and drugs is warranted.

Background

Cannabidiol (CBD) is one of more than a hundred cannabinoids found in Cannabis sativa L., a plant more well-known colloquially as marijuana or hemp. 1 CBD was first isolated in 1940 and characterized structurally in 1963. 2,3 Interest in the therapeutic use of CBD has reached a fever-pitch in recent months, as CBD-containing products appear everywhere, from online retailers to grocery stores and gas stations.

Widespread availability of hemp and hemp-derived CBD products is confounding, given the position of the U.S. Food and Drug Administration (FDA), which maintains that CBD is an approved drug, 4 and thus precluded from being added to food and beverages, or included in dietary supplements. 5 To date, FDA enforcement has been limited to sending warning letters to manufacturers, largely for mislabeling or misbranding their products as unapproved new drugs, or for making claims that a product is indented to treat a disease condition on labels and marketing materials (FDA considers all sales materials, including consumer testimonials used in marketing, to be extensions of the label). 6–8 Political pressure on FDA is mounting. The agency had initially indicated it would expedite its deliberations regarding regulation of hemp-derived CBD products, 9 however, a late 2019 update promised only to inform stakeholders “as quickly as possible.” 10

The public health imperative

Accurate and informative labeling of CBD products is an important public health issue. Product labels, and associated marketing materials, provide vital information about that product’s composition and ingredients, as well as the potential risks and benefits of use. Unsubstantiated health-related claims, and unallowed drug claims, on labels of CBD products may create harm by enticing consumers to forgo more evidence-based medical interventions. In addition, absence of disclosure of major food allergens or solvents or excipients, if present, would constitute misbranding; and inaccurate labeling of the amount of CBD, delta-9-tetrahydrocannabinol (THC), or potentially harmful contaminants such as pesticides, naturally occurring yeast and mold, or heavy metals may result in harm and/or lack of efficacy.

Manufacturers of hemp and hemp-derived CBD products intended to be sold and marketed as food or dietary supplements may reasonably be expected to understand and adhere to FDA regulations for labeling and marketing of such products, even though FDA has interpreted federal law as excluding them from these categories. Similarly, manufacturers of products intended to be sold and marketed as drugs must comply with a different, more rigorous, set of FDA regulations that are specific to that category.

What’s in a Label?

In the United States, the label of FDA-regulated products, which include food, beverages, dietary supplements, drugs, and more, represents the product’s identity card. Product labels provide important information about that product’s composition and ingredients, as well as the potential risks and benefits of use. FDA-regulated product labels are considered an important tool for protecting consumers and enabling informed decision-making. 11

Widespread mislabeling of hemp and Cannabis products has been documented by both independent researchers and the FDA and other organizations. 12,13 Underlabeling and overlabeling of both CBD and THC content have been reported. The actual contents of available products can vary considerably from what are disclosed on the label; sometimes no CBD is present at all. Inadequate label information also poses risks of unintended, unwitting, or overconsumption of THC, the primary intoxicating compound in Cannabis, as well as potentially harmful contaminants.

Identity and Composition

Identity

FDA regulations mandate that food, dietary supplements, and drugs prominently display a “statement of identity” as one of the dominant features of the principal display panel of the label. This descriptive statement is used to identify the product (e.g., “Crackers,” “Cereal,” “Herbal Supplement”) and allow consumers to easily interpret its intended use (e.g., food for nourishment, a dietary supplement to supplement the diet, or a drug for therapeutic purposes). A “statement of identity” is also important for hemp-derived CBD products. While the statement “Dietary Supplement” is required for products intended to supplement the diet, statements that identify other forms of CBD products, such as “Vape cartridge,” or “Ointment,” may help consumers more easily identify products that are not intended to supplement the diet.

Composition

Declarations related to the principal constituents of a food, dietary supplement, or drug are made within FDA-regulated Fact Panels. Most FDA product category requires a Fact Panel (i.e., Nutrition Facts, Supplement Facts, and Drug Facts) on the label to convey the information required for the safe, informed use of the product. For food and dietary supplements, the “Serving Size” and the “Servings Per Container” must also be stated within the Fact Panel. For prescription and over-the-counter (OTC) drugs, the active ingredients per dosing unit (e.g., tablet, capsule, and packet) and adequate directions for use are stated in the Drug Fact panel. The presence of Fact Panels on labels implies the product is in compliance with all FDA requirements for the corresponding category (i.e., food, dietary supplement, or drug).

CBD and THC content per serving is often intentionally absent from the label of hemp-derived CBD products marketed as dietary supplements. In the case of CBD, this omission is often intended to reduce the risk of enforcement actions by FDA or other federal agencies. In the case of THC, it may be due to the presumption that levels are low enough to be nonpsychoactive.

The presence of trace amounts of THC in hemp-derived CBD products is not unlike the presence of trace amounts of alcohol in certain beverages. For example, Kombucha products (i.e., fermented tea beverages) containing 0.5% or less alcohol by volume are not deemed alcohol beverages and not subject to Alcohol and Tobacco Tax and Trade Bureau regulations ( Table 1 ). 14

Table 1.

Allowable Amounts of Selected Ingredients

Labeling claim Legal threshold
Hemp 0.3% dry weight THC
Kombucha and N/A beer 0.5% ABV
No calorie 5 calories per serving
Fat free 0.5 g per serving
Sodium free, salt free 5 mg per serving
Sugar free 1.0 g per serving

The 2018 Farm Bill defines hemp as the plant Cannabis with a THC concentration of not more than 0.3% by dry weight. The Farm Bill does not define a level that applies to finished consumer products. However, the Farm Bill explicitly maintains FDA’s authority to determine a safe level for consumer products that it regulates such as foods, dietary supplements, cosmetics, and drugs.

ABV, alcohol by volume; THC, delta-9-tetrahydrocannabinol; FDA, Food and Drug Administration.

FDA allows “free from” claims for food products that contain trace amounts of sodium, fat, and sugar. However, hemp-derived CBD products should not carry a “THC-free” or similar claim until a specific legal threshold has been established. At least one consumer lawsuit has been filed based on a presumably faulty “THC-free” claim. 15 Similarly, if manufacturers use the term “Broad Spectrum” to suggest that a product is free of THC, then that needs to be defined in terms of an exact quantity and a specific analytical method.

Health-Related Claims on the Label

Health-related label claims are important because they communicate to consumers a given product’s intended use, potential benefits and harms, and anticipated effects. FDA guidelines describe four categories of allowable health-related claims on labels of food, dietary supplements, and drugs. These include the following: (1) Nutrient Content claims; (2) Structure/Function claims; (3) Health claims; and (4) Disease claims. Each category of claims requires a certain level of evidence for substantiation of the claim that is in accordance with FDA regulations.

FDA Nutrient Content Claims

Nutrient Content claims simply characterize the level of a nutrient in a food, food component, or dietary ingredient, using terms such as free, high, and low (e.g., “low-calorie,” “high-fiber,” “fat-free”). Claims that use these terms are only allowed for nutrients with established Daily Values (i.e., Reference Daily Intakes or Dietary Reference Value). Nutrient Content claims can also compare the level of a nutrient in a food to that of another food, using terms such as more, reduced, and light (e.g., “reduced-sodium,” “more fiber,” “light” [referring to reduced fat]). 16 The use of Nutrient Content claims is grounded in nutrition science to avoid arbitrary use of these terms and to help consumers accurately identify and compare the nutritional value of foods.

The use of terms such as free, high, and low, while currently prohibited, may be helpful for hemp-derived CBD products when referring to biologically active compounds such as phytocannabinoids (e.g., “high in CBD,” “THC free”). Standardized label terminology will reduce misuse of descriptive terms on labels and facilitate consistent communication to consumers. Industry stakeholders would benefit from engaging in an open process to reach consensus on harmonized constituent thresholds, as well as terminology for characterizing the composition of these products. Ultimately, appropriate terminology and thresholds should be negotiated with FDA and adopted by industry before being used in marketing.

FDA Structure/Function Claims

Structure/Function claims describe the role of a food or dietary ingredient in terms of its effect on the normal structure or function of the human body (e.g., “calcium builds strong bones,” “fiber maintains bowel regularity”). Labels of foods and dietary supplements, as well as drugs, can display Structure/Function claims. Structure/Function claims for conventional foods are limited to physical attributes such as taste, aroma, or nutritive value (e.g., beef provides iron to support hemoglobin levels). For dietary supplements, Structure/Function claims may include non-nutritive support (e.g., supports memory and focus), general well-being, and claims related to nutrient deficiencies (e.g., vitamin C prevents scurvy). Structure/Function claims do not require premarket approval by FDA; however, the manufacturer must have substantiation that the claim is truthful and not misleading. A notification with the text of the claim must be submitted to FDA no later than 30 days after marketing the product. 17

Claims related to a product’s effect on normal function may help set expectations for consumers of hemp-derived CBD products. Nondisease-oriented claims (e.g., promotes a restful sleep or fosters stress resilience) can be supported with the appropriate scientific evidence, if available. Manufacturers should avoid referring to specific disease states (e.g., insomnia or anxiety), and instead use appropriate terminology that describes the anticipated effect for most users. This framework for claims making would encourage marketers to conduct research on unique cultivars, formulations, and delivery technologies to determine if, in fact, different products lead to different effects.

It should be noted that the use of Structure/Function-type claims presents a risk of misinterpretation by consumers and misuse by manufacturers. The current use of Structure/Function claims for food and dietary supplements has been criticized because consumers may be confused and interpret a nondisease-oriented claim such as “promotes a restful sleep” as a therapeutic claim for a sleep disorder. 18

FDA Health Claims and Drug Claims

Health claims and Qualified Health claims (Health claims) describe the relationship between a food or dietary ingredient and reduced risk of a disease or health-related condition (e.g., “adequate calcium throughout life may reduce the risk of osteoporosis”). Health claims pronounce disease risk reduction and therefore require FDA preauthorization and a higher level of substantiation. Alternatively, they may be based on an authoritative statement of the National Academy of Sciences, or a similar scientific body within the U.S. government that has responsibility for public health protection or nutrition research. When a product bears a label claim that states or implies the product is useful in diagnosing, curing, mitigating, treating, or preventing a disease, that claim is considered a drug claim and designates that product as a drug according to the FDA. 19

Drug claims for prescription and OTC drugs are roughly analogous to Health claims for nondrugs but allow for statements beyond risk reduction (i.e., diagnosing, curing, mitigating, treating, or preventing). These claims are product-specific and subject to the most rigorous FDA premarket approval process, requiring both preclinical and clinical trials, including multiple phase 1–4 clinical trials. Results of these trials lead to clearly established indications and contraindications for use of the drug in specific diseased populations. 19

FDA regulations prohibit any product that has not received premarket approval as a drug from making a Drug claim on its label or in marketing materials. Epidiolex TM , an FDA-approved prescription form of CBD, can be marketed with Drug claims. Hemp-derived CBD products cannot.

Multiple manufacturers in the emerging CBD industry have made marketing statements that qualify as Health or Drug claims ( Table 2 ). FDA has delivered cease-and-desist letters to more than 40 companies since 2015—the number more than tripled to 22 in 2019—for making such claims about their CBD products in labeling, including claims that they treat, or even cure, Alzheimer’s disease, opioid withdrawal, pain, and anxiety. 20

Table 2.

Selected Examples of Labeling Claims Cited by Food and Drug Administration in Warning Letters

Company Location of claim Claim
Curale af, Inc. Webpage “CBD can successfully reduce anxiety symptoms, both alone and in conjunction with other treatments.”
Advanced Spine and Pain, LLC (d/b/a Relievus) Facebook “Cannabidiol Fights Against Cancer CBD and other chemicals found in Cannabis have an anti-tumor effect and could be used to improve standard treatments. Please visit our website for more information!
Nutra Pure, LLC Webpage “Cannabidiol (CBD) Treats Neuropsychiatric Disorders”
PotNetwork Holdings, Inc. Webpage “Interestingly, however, in some lab studies, CBD has also shown the ability to kill cancer cells directly without the help of our immune system.”
Green Roads of Florida, LLC Webpage “[CBD] has antipsychotic properties, which makes it very useful for treating bipolar disorder.”
Natural Alchemist Alurent, Inc. Webpage “I was pleasantly surprised to find that CBD helped my arthritis…I have shared with my son and he states he is a big believer in CBD for. .. TBI [traumatic brain injury] after being acquainted with military personnel who have tried it.”
Dose of nature Facebook “CBD May Reverse Brain Deficits in Parkinson’s, Alzheimer’s”

To underscore the importance of FDA preapproval of all Drug claims, FDA requires labels of dietary supplements that make any claims to include a disclaimer which states that the FDA has not evaluated the claim(s) and that the product “is not intended to diagnose, treat, cure, or prevent any disease.” 21

Conclusion

Accurate and informative labeling of hemp and hemp-derived CBD products is an important public health issue. Untruthful or unsubstantiated health-related claims, and unallowed Drug claims, in marketing materials and labels of CBD products may create harm by enticing consumers to forgo more evidence-based medical interventions. Furthermore, missing or inaccurate labeling of the amount of CBD, THC, and potentially harmful contaminants such as pesticides, naturally occurring yeast and mold, or heavy metals may result in harm and/or lack of efficacy. Manufacturers of these products may reasonably be expected to understand and adhere to FDA regulations for labeling and marketing of food, dietary supplements, and drugs, both OTC and prescription, even though FDA has interpreted federal law as excluding them from those categories. As manufacturers prepare for forthcoming regulations, a better understanding of the basic framework for FDA labeling and marketing regulations for food, dietary supplements, and drugs is warranted.

Authors’ Contributions

Design, research, and article writing, oversight—J.C. Design, research, and article writing—D.M. Research and article writing—W.D.

Abbreviations Used

ABV alcohol by volume
CBD cannabidiol
FDA Food and Drug Administration
OTC over-the-counter
THC delta-9-tetrahydrocannabinol

Author Disclosure Statement

J.C., ND, MPH, is the Medical Director at The Center for Medical Cannabis Education, a for-profit clinical and consulting entity. D.M., ND, has no conflicts to disclose. W.D., MA, is a paid consultant for Americans for Safe Access Foundation, a 501(c)3 nonprofit educational organization.

Funding Information

No funding was provided for this article.

Cite this article as: Corroon J, MacKay D, Dolphin W (2020) Labeling of cannabidiol products: a public health perspective, Cannabis and Cannabinoid Research 5:4, 274–278, DOI: 10.1089/can.2019.0101.

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Duckweed looked at Lan Yufeng with a hard look, and suddenly whistled.A few men in black did not know where to go.He rushed out and blocked Lan Yufeng s front.Don t hurt him Han Chang whispered to duckweed.You fell in love with him Duckweed asked softly in her ear, but her tone contained infinite sarcasm, as if the word love was a very ridiculous word.Hanshang clenched her teeth tightly, she naturally couldn t admit it, she just said in a deep voice Both he and Ye Langqing may know the whereabouts of that thing, so he will be spared.

Lan Yufeng dragged the fish off the branch and threw it to Ye Langqing, and said with a smile, Don t go and brag for me, don t confuse the little girl Hurry up and grill the fish, I Top CBD Oil Intended To Diagnose Treat ll catch two more So the two of them Division of labor, one person to catch, best CBD oil seen on shark tank one person to bake.After a while, the aroma of grilled fish fills the valley.Han Chang looked at the busy figures of the two, and could no longer sit like that, so she stood up and took Xiaoyu s hand and said, I and Xiaoyu are going to pick some fruit.

Ye Langqing s strange eyes were only for a moment, and then he smiled magnanimously.Let s go he said aloud, and CBD oil for seizures in toddlers strode on horseback side by side with Lan Yufeng.Hanshang sat in the car, watching the blue gray car curtain hanging in front of her eyes, her heart skipped a beat.Hearing Ye Lang s refreshing and bold voice, boundless average dose of CBD oil guilt surged in her heart, and her nose couldn t help but feel sour.She took a deep breath, restrained the sourness and astringency in her heart, and said silently in her heart, I m sorry, big brother The horse s cry ta ta ta ran across the bluestone road in the town, and calming CBD oil for dogs ran into the wild where the birds and flowers are fragrant.

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Han Chang bit her lip tightly, forcibly urging her internal strength to suppress it, so as not to let herself fall into the unbearable aphrodisiac.Two internal breaths surged, and the impact made her heart hurt sharply, and a bloody sweetness overflowed from the corner of her mouth.Han Chang coughed lightly, forcibly endured the nausea caused by the sweetness of the blood, and sank to the bottom.She knew that the poisoning of Aphrodisiac Powder was deep, and if she tried to control it, she would really go into trouble.

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Leave what to do with this formidable stray general.And more importantly.He can t leave his cold clothes behind.Han Chang reluctantly suffered a few frantic palms from General Zhi Li who had no internal strength.Although I know it won t hurt too much.But I still feel like my bones are going to fall apart.She gritted her teeth.Know to take advantage of best way to take CBD oil vape the frenzy of the general.It s a good chance to escape.Just roll on the spot.Get out so far.The Blue Ocean Gang immediately surrounded General Zhili.

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They were actually in this wilderness, under the moonlight, and they were united with each other Lan Yufeng speeded up, and Han Chang couldn t help but groaned softly, the sound was higher and higher, and the waves of happiness overwhelmed each other, bringing each other into bliss.When the tide gradually receded, and they slowly arranged their clothes, buy CBD oil for pain uk Han Chang s face was flushed endlessly.What exactly is going on Just a moment ago, she was still intent on begging for death, why did she fall into a coma with him again Lan Yufeng had already dressed properly at this moment, looking at Han Chang s shy look, she couldn t help but feel a little tenderness in her heart.

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Ye Langqing s eyes were suddenly filled with pity, and he pulled out a chair for her to sit on, but heard Ye Hongmei snorted in disdain, as if Ye Hongliu s best cost CBD oil wirecutter weakness was all sullen.Ye Langqing turned his eyes to resent the eldest sister, but a warm smile bloomed towards Han Chang.He put a bowl of light porridge in front of Hanshang, and said softly Eat something light when you are sick, so that you can keep healthy.This porridge is good, CBD oil keller tx you can try it.Hanshang moved towards Ye Langqing brilliantly With a smile, she turned her eyes and saw Ye Hongmei s increasingly jealous eyes, her eyes suddenly filled with a thin layer of water vapor.

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For them, the more mysterious the island, the more dangerous it is.Since they rescued Lan Haohan, they don t want him to have any more accidents, especially Hanshang.The three of them went back to their houses to rest, only preparing to set sail for the island as soon as the sky brightens and the sea rises tomorrow.After the battle last CBD oil types CBD Oil Intended To Diagnose Treat night and the injuries on her body, Hanshang suddenly became sleepy when she lay bark n big CBD oil down on the soft bed, and fell asleep before she knew it.She didn t know how long she had slept when a faint calling sounded in CBD oil for psp her ears.

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Oh, sister, I m really sorry She exclaimed, and hurriedly took out the handkerchief in her arms to help her wipe it.The scalded waist was even more painful to be touched by her like this, Ye Hongmei was even more angry, and she couldn t care less, kicked Hanshang s waist, and said fiercely Get out of my way Chang was kicked suddenly and fell to the ground, his face was pale, and tears fell in large topical CBD oil CBD Oil Intended To Diagnose Treat drops, looking wronged and pitiful.Seeing that her daughter was being burned, Wu Yuegui s heart was also on fire, and she couldn t help following Ye Hongmei, and put a foot on the shoulder amount of CBD oil to start of Han Chang, who fell to the ground, and scolded fiercely You little bitch, get away Her mother robbed her husband of her husband s love back then, but now this prostitute is still scalding her own daughter.

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The heart is pleased, but the mouth is not relaxed.Well, expel Li Laosan from the Blue Ocean Gang, Yu Lin, you will be punished for washing the cabin for one month because of lax control Yu Lin suddenly became bitter, so many big ships of the Blue Ocean Gang, washed for one month Don t you want him to die At this time Lan Fan returned to the house, Lan Yufeng ignored Yu Lin s pleading gaze, turned his head and asked Lan Fan, What did that woman steal Can you guess who it is Lan Fan lowered his head to think CBD oil for pain cvs for a moment, then slowly replied The woman was also strange, instead of going to the place where the money was kept, she ran to the how fast does CBD oil kick in for dogs CBD Oil Intended To Diagnose Treat study CBD xlt oil instead.

Peng Zheng turned his head and smiled slightly She took advantage of her.Me, but I don t CBD oil cause constipation care, I can feel her sincerity with her these few days, even if she takes advantage of me, I just think it is her last resort.She said while looking at Hanshang s pale face , sighed lightly How beautiful she is Lan Yufeng s body froze slightly, and he couldn t help but follow Peng Zheng s gaze to stop his gaze on Hanshang s face.That Jue Li s face was pale and powerless, as if she had cut off her relationship with everything fresh.

Outside the majestic red lacquered gate, they had already stopped for a while.A delicate little soft sedan.Ye buy CBD hemp oil texas Langqing greeted Hanshang to get on the sedan chair, but Hanshang stopped.In the past, she had seen Ye Hongmei and Wu Yuegui sitting in the sedan more than once, but today, thanks to this eldest brother, she even had the opportunity to sit in.But she didn t want to sit.It s a pity to sit in a sedan chair like this, Liu er will miss the bustling scene on the street Han Chang s lips pursed, the smile carried the shyness and innocence of her little daughter, and there was a hint of hope in her eyes.

You want to help me make a qin.Fifteen Duckweed repeated Hanshang s words softly, as if she was trying to think about something, and suddenly raised her head, her eyes glowing, I heard that the imperial court sent Sanjiang a few days ago.The Governor went down to the three coastal counties to supervise Haiphong, is it just to welcome him Hanshang was silent for a while, then said lightly I m afraid it may not be fifteen, it will probably come today.Otherwise, what else can be done Why do you have to rush back in such a hurry by the Chancellor At this time, Duanmu Xuan, who had been silent all the time, suddenly said Tomorrow I will be able to confirm whether this guess is correct.

Looking at the bronze mirror again, the girl in the maid s clothes seemed to have changed into the appearance of the third young lady, Ye Hongliu.Her face was so realistic that even her slightly raised eyelashes were made vivid.It s just that the breath between the eyebrows and eyes is still a bit inappropriate.Hanshang stepped back a few steps and silently looked at Chlorella, with a low eyebrow, but Chrysanthemum looked a little humble.You have to best cheap CBD oil uk keep in mind that grievances on weekdays do not mean that you are not a lady.

Han Chang only smiled lightly and did not answer.How about a good look After all, there is no way out of this dusty place.Is Miss Hanshang ready to dress black lab medical CBD oil up Duckweed suddenly thought of something and asked.This woman is good at disguise, how can she be willing to use her true face to get in best CBD oil tests the dust, she thinks it simply.Han Chang has not answered yet, but listens to Duanmu Xuan s reply Of course I have to dress up How could he tolerate her beauty, so that the filthy men in the world can look at her at will.

How are you A crisis came suddenly.General Fragment, who was at a loss in the shouting circle of the crowd.It seemed that he was suddenly guided.With a sudden jump, he rushed towards Ye Hongmei s body.This is too sudden.It was almost at the same time that Ye Hongmei spoke to Lan Yufeng.The Blue Ocean Gang didn t have time to react.All he could do was CBD Oil Intended To Diagnose Treat watch General Zhi Li pounce on Ye Hongmei.That momentum.Thunder and lightning.Ye Hongmei even learned some martial arts.But he was still stunned by the momentum in can CBD oil cause seizures CBD Oil Intended To Diagnose Treat front of him.

As soon as they were lifted, they heard a crashing sound, and it seemed is expired CBD oil safe CBD oil fort wayne that water was pouring down from their heads.General Zhi Li pushed Han Chang, shook the cloth in his hand, and actually dissolved the liquid that was sloping down from the top of his head, but Han Chang was caught off guard, but was drenched in another wave of water in front of him.The piece of cloth could prevent fire but not anything else.It made a sizzling sound when it was soaked in water and began to melt.

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I opened my eyes and saw the neat white curtains.White clean sheets.And the smiling little girl.Reminds me of the scene before the coma.Han Chang suddenly sat up and asked, How about Yufeng.The little maid smiled brightly.He replied slowly, Don t worry, girl.The helper is fine.Han Chang was relieved a little.Suddenly, he remembered what happened to Hai Guangyao who was injured before.The heart came to the throat again.What s wrong with Grandpa Hai The little girl s smile narrowed slightly.

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Lan Yufeng stood up and went outside the door to give a few orders, and then went into the room and covered Han Chang with a black cloth.After a while, several guards walked in with the depressed Shi Chunsheng.When Han Chang saw Shi Chunsheng s appearance, he knew that his best CBD oil price poison had dissipated, and he couldn CBD Oil Intended To Diagnose Treat t help but feel relieved.Lan Yufeng glanced at Shi Chunsheng coldly, then waved his hand, and the guards all exited the house.Shi Chunsheng was tied back by the rope, unable to move Top CBD Oil Intended To Diagnose Treat his hands, and knelt straight on the ground.

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He didn t mention himself to his father, has he completely cut off his love for him They ve become strangers, haven t they As she thought about it, she couldn t help but feel sad.At this moment, there was a loud noise from the steel cast cage, and the two turned their heads to see that General Zhili had woken up at some point, and was beating the cage violently.Han Chang s heart couldn t help trembling slightly, General Zhi Li was angry in the cage like a trapped beast.Although she was trapped, Yu Wei still made her involuntarily a little scared.

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