CBD Oil Tolerance


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If you've recently found your CBD oil ineffective or you've never had any luck with CBD oils, your dose may be to blame. However, there can also be other factors at play, including poor quality CBD oils or how you're taking CBD. Over time, as we introduce either plant-based or synthetic compounds into our bodies, we be CBD is very different from other cannabinoids, but does prolonged use of CBD oil cause the user to build up a tolerance? Why are some users talking about the reversed tolerance phenomenon? Much like other substances we ingest in our everyday lives, CBD users can build up a tolerance to the cannabinoid compound over time.

Can You Build CBD Tolerance?

If you’ve recently found your CBD oil ineffective or you’ve never had any luck with CBD oils, your dose may be to blame. However, there can also be other factors at play, including poor quality CBD oils or how you’re taking CBD.

Over time, as we introduce either plant-based or synthetic compounds into our bodies, we begin to develop tolerance. Due to this phenomenon, you may need higher doses of the substance to get the same level of desired effect unlike THC.

We’ll break down everything you need to know about CBD tolerance, safety, and how to source quality CBD products in this article.

Can You Take Too Much CBD?

Yes, you can take too much CBD.

That being said, CBD has been proven safe, even in high quantities, and won’t lead to lethal overdose [1]. But this isn’t to say you won’t experience any discomfort if you take too much. Any compound that alters the way you feel has the potential for adverse side-effects — though some much more severe than others.

Here are some common side effects of CBD overdose:

Thankfully, the aftermath of taking too much CBD wears off as soon as it’s out of your system, within 2–3 hours. However, to avoid any chances of discomfort, you should start with lower doses and build up gradually over time until you reach your desired effects.

Keep in mind, CBD can create undesired outcomes when taken with other medications, which is why you must speak with your doctor before using CBD oil to treat a condition.

5 Reasons Why CBD is Not Working for You

It can be frustrating to try numerous CBD products, only to find nothing but wasted money and disappointment in your purchases. There can be several contributing factors as to why your CBD is not working and here we’ll go over the common problems while offering solutions for each.

1. You’re Using Low-Quality CBD Products

The CBD industry is relatively new and poorly regulated. Unfortunately, there are companies out there selling fake CBD oil that contains very little CBD or harvesting CBD from contaminated hemp sources.

Before you purchase a CBD product, check for third-party lab tests and read online consumer reviews.

Reputable brands send samples of their products to non-biased, third-party labs to ensure quality control measures are met. These labs test for CBD content and potential contamination from harmful solvents, heavy metals, pesticides, or mycotoxins (mold).

You want to verify that the CBD content on the test matches and fewer cannabinoid receptors what’s labeled on the bottle and that the extract is free from contamination that can render the CBD ineffective or potentially dangerous.

2. You Need To Find The Right Dose

If you’re just getting started with CBD and you’re not getting the desired effects, chances are you haven’t found the right dose. The tricky thing about dosing is that everyone responds to CBD differently. Your ideal dose will depend on various factors, including genetics, experience with medical cannabis, metabolism, and health conditions.

You can expect to experiment with your CBD doses, but start with smaller amounts and build up gradually over a few days until you find your Goldilocks zone. It may help to make note of your doses in a journal or your notes app on your phone to track how much CBD you’re taking.

3. You Need To Use CBD Consistently

While CBD has been proven effective for many health benefits, it’s not an overnight fix-all compound.

People will often buy CBD oil thinking it works like Tylenol for instant pain relief — but it just doesn’t work that way. Aside from finding the appropriate dose unique to you, it can take CBD days or several weeks of THC tolerance before you experience a noticeable difference in how you feel.

CBD isn’t particularly good at binding to receptors that activate an immediate response. Consistent use of CBD oil maintains the body’s endocannabinoid system function by making the receptors more sensitive to stimulation from internal cannabinoids.

In addition to giving prescription medications CBD some time to work, we recommend taking your CBD at the same time each day with your vitamins for overall health support or an hour before bed as part of your winding down routine if you’re looking to use CBD to improve sleep quality.

4. You’re Using The Wrong Delivery Method

Cannabinoid receptors are located throughout the body, which allows CBD users to enjoy different delivery methods for consuming CBD from CBD oils, capsules, sprays, gummies, and skincare.

However, the effects you’re looking to experience with CBD can depend on the delivery method you choose. For example, topical CBD formulas like lotions and salves work well for relieving localized muscle aches from a strenuous gym session, but it won’t help support a normal digestive process or mood because it doesn’t enter the bloodstream.

Do you find vaping CBD products to work well initially, but it seems to taper off quickly? This is because CBD inhalation is the fastest delivery method as it bypasses the digestive system that can breakdown the active compounds before entering the bloodstream. However, the effects of smoking CBD also wear off faster.

If this is the issue, consider taking a break from smokable products and use edible forms of CBD instead such as capsules, oils, or gummies.

5. You’ve Built A Tolerance To CBD

It’s possible that you’ve built a tolerance to CBD when you feel like your CBD product isn’t working as well as it used to.

Long term CBD users are likely to experience tolerance and have to increase their doses to get the same level of effects. A high tolerance can make CBD use expensive. However, it’s possible to reduce your threshold if you take a CBD tolerance break.

A tolerance break means you stop taking the substance you’ve built a tolerance to in order to let it completely run its course from your system. There isn’t a scientific rule for how long you should take a break from CBD — but many people report 3-7 days seems to do the trick to reset their system.

Tolerance breaks, much like dosing CBD, is an individual affair that requires experimentation and observation. It may be helpful to record your doses before you go on a tolerance break so you can have a reference to look back on for future dosing with a more accurate assessment of your condition before, during, and after you temporarily abstain from CBD use.

Here’s what to record if you should decide to take a CBD tolerance break: how long you’ve been using CBD, your doses before the break, symptoms, how many days of tolerance break, symptoms during break, doses after the break, increasing doses gradually, note any changes in symptoms or side-effects.

How Fast Does CBD Tolerance Build?

It’s difficult to say how quickly CBD oil tolerance builds because it’s different for every individual and your CBD doses may fluctuate depending on the state of your health and your current lifestyle.

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The endocannabinoid system is responsible for regulating homeostasis (balance) in the body, which means you may need more or less CBD at any given time. Dosing CBD oil that’s right for you comes with a lot of trial and practice — so there’s no one size fits all approach to dosing.

Tolerance depends on a variety of factors, including:

CBD Tolerance vs. CBD Dependence

Defining Substance Tolerance

The word tolerance is often associated with drug addiction and the negative consequences of a condition called dependence that can be dangerous. Let’s quickly run through the differences of substance tolerance and dependence.

Tolerance is what occurs when your body loses sensitivity to a compound to elicit the desired outcome. Just as you can build a tolerance to caffeine, your system can build a tolerance to CBD.

The effect of tolerance makes users consume more of the substance to achieve the same level of impact because their body has lost sensitivity to the active compound.

Defining Substance Dependence & Withdrawals

Dependence is what happens when a user goes through withdrawal symptoms, which can include both physical and emotional disruption.

Withdrawal symptoms can be as mild as headaches, moodiness, or fatigue due to caffeine withdrawals, or more life-threatening, such as a fast heart rate, muscle pain, depression, and vomiting from withdrawals.

These severe withdrawals create a dependence on the substance in order to avoid adverse symptoms. The body becomes dependent on the compound and now needs it to reach a level of homeostasis (balance).

When it comes to CBD, you can build a tolerance. However, severe withdrawal symptoms are highly unlikely to develop, even for long term users [2]. The most discomfort felt in a randomized CBD trial that investigated what happens when users take an abrupt break from regular use included headaches and diarrhea.

You’re not likely to experience a CBD dependence because it doesn’t produce withdrawal symptoms when you’re not using it.

What Is Reverse Tolerance?

Reverse tolerance is when you require less of a compound to reach the desired effects — opposite to building tolerance. You become more sensitive to the compound, which can be a positive or negative, depending on the compound.

Some anecdotal evidence suggests that CBD has this reverse tolerance effect with long-term use, but there’s still a lot of medical research needed to confirm this. It’s more likely that it takes a long time to develop a tolerance to CBD in general because of it’s unique interaction with the endocannabinoid system.

Our body’s receptors rely on chemical messengers to send signals for actions within the body. Most compounds that build tolerance in the body bind with these receptors to elicit a specific action. With prolonged exposure to the chemical messenger, the receptors lose their sensitivity.

CBD isn’t efficient at binding to CB1 or CB2 receptors, like its famous psychoactive counterpart, THC is.

Continued use of THC has been shown to increase the body’s tolerance [3]. However, consuming CBD with THC has shown to improve THC interactions, which is one of the reasons that have lead researchers to believe that CBD tolerance either isn’t real or there is a reverse tolerance occurring.

CBD doesn’t directly unlock actions on the CB1 or CB2 receptors in the endocannabinoid system. Rather, CBD promotes receptor activity, which helps facilitate the binding of the cannabinoids to receptors, and CBD prevents the breakdown of internally produced cannabinoids.

To Wrap Up: CBD Tolerance

Can you build a tolerance to CBD? Yes, it’s possible.

However, CBD’s unique interaction with cannabinoid receptors makes it difficult to study the mechanisms for tolerance. CBD has such varied effects on individuals long term that people may experience the phenomenon of reverse tolerance, but there’s still more research to be done to substantiate this.

What do you do if your CBD product is no longer working as well as it should or if you’ve never had any luck with CBD?

Make sure you’re buying CBD from reputable brands. There’s a lot of misinformation surrounding CBD — steer clear from brands offering too-good-to-be-true medical claims.

Look for brands that opt for non-biased third-party lab testing to prove the product’s CBD content and safety.

Additionally, you should experiment with your doses and delivery methods (as your needs may change over time), and if you’ve built a tolerance to CBD, it’s a good idea to take a break once in a while.

Luckily, CBD is a well-tolerated compound, and there are many different delivery methods you can experiment with to help you find the most desired outcome. If you’re interested in learning more about CBD, visit our blog for more resources.


The statements made regarding these products have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from health care practitioners. Please consult your health care professional about potential interactions or other possible complications before using any product.

CBD Tolerance: Can You Build Up A Resistance Over Time?

Most people taking CBD report consistent effects of the same doses with prolonged use. Does it mean that CBD tolerance is a myth?

Substance tolerance is a familiar concept to all people who take supplements and medications. The human body is very flexible at adapting to different substances — lowering their effectiveness over time.

Considering that CBD is a supplement that people take daily, it’s no wonder they ask questions about the risk of building a tolerance.

So, will you build a tolerance to CBD if you take it often?

Studies conducted on the safety and efficacy of CBD oil hold the answer.

Continue reading to learn more.

Can You Build a Tolerance to CBD?

Like we said, building a tolerance to any substance is a common concept. Many of us experience it in our daily routine. When you drink coffee or tea, you need stronger dose overtime to get the same focus and energy as you did, say, a few months ago — especially if you’re a daily user.

CBD is consumed frequently; for most people, it means taking CBD twice a day; some users, however, use it four times a day because they need more CBD oil in their situation. If CBD actually holds the risk of building a tolerance, it should abide by specific mechanisms that most supplements and medications use.

Let’s elaborate on why people build a tolerance to certain substances.

How Tolerance Works

Tolerance is categorized into three major groups: behavioral, cellular, and metabolic.

Behavioral tolerance is where we become psychologically adapted to the effects of a substance; cellular tolerance involves cells becoming less responsive to a compound, which is why you need more coffee to stimulate the body when you drink it regularly. Metabolic tolerance, in turn, means that lower concentrations of a substance reach the target area.

Tolerance doesn’t have to belong to one of the three aforementioned categories and can show the symptoms of all three mechanisms depending on the interaction between a particular substance and the body.

Tolerance affects every person differently; there are different rates at which we become tolerant to a substance. Our genetic structure, physiology, history of substance abuse, as well as environmental factors, may determine how fast you build up a tolerance to substances. For some people, it may take a bit more time to develop tolerance, while others build it very quickly.

When it comes to cannabinoids, tolerance is noticeable mostly on the cellular level. Over time, the endocannabinoid receptors may become desensitized, meaning they’re less enthusiastic about interacting with the administered compound, and in some cases, will hide inside a cell so they cannot be reached by the cannabinoid.

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It appears this isn’t the case with CBD.

What Happens Inside Your Body When You Take CBD?

CBD has a unique fashion of interacting with the endocannabinoid system. Rather than binding to CB1 and CB2 receptors, it affects them more indirectly. A study conducted by the Department of Neuropharmacology at Fukuoka University reveals that “the neuroprotective effects of cannabidiol are independent of CB1 blockade,” suggesting that it doesn’t work by binding directly to the receptor and shouldn’t theoretically build a tolerance. (1)

CBD uses a different mechanism, one that allows it to encourage the production of endocannabinoids and improve the binding affinity of specific receptors in the body. Through this mechanism, CBD helps the endocannabinoid system to maintain balance (homeostasis) between all vital processes within the body (2).

So, rather than forcing the endocannabinoid system to become overactive and less responsive to the compound over time, CBD enhances its functioning by modulating the activity of its receptors and ensuring more efficient use of the body’s own cannabinoids.

CBD Tolerance vs THC Tolerance

People who use THC-rich cannabis may build a tolerance to the cannabinoid because it has a direct affinity to the CB1 receptor in the brain. This is why THC gets us high and CBD doesn’t. Daily use of THC causes the user to experience less pronounced effects with the same amount of cannabis.

As mentioned, THC tolerance happens on the cellular level. THC interacts with the brain by binding with CB1 receptors. When this process is repeated regularly, the cells try to maintain normal CB1 activity by reversing the THC’s effects. They trigger this effect either through desensitization, where CB1 receptors make it difficult for THC to bind with them, or through internalization, which is the process by which CB1 receptors hide into the cell’s interior. When internalized, the cells become entirely unresponsive (3).

How Fast Does CBD Tolerance Build?

Although it’s not possible to build a tolerance to CBD, we all have a different tolerance threshold that may change over time. In other words, you may need more CBD after two years of regular use, but it doesn’t necessarily derive from building a tolerance, but rather from the changes in your endocannabinoid system and overall body chemistry.

Tolerance and its fluctuation vary depending on the following factors:

  • Age
  • Genetics
  • Gender
  • Metabolism
  • Weight
  • How much CBD you’re taking
  • Experience with CBD

CBD Tolerance vs. CBD Dependence

The term tolerance often has a negative connotation; most people associate it with drug addiction. However, this word is often wrongly used instead of dependence, which is the accurate term to describe what happens to drug users over time.

  • Tolerance is what you experience when your body becomes less sensitive to a compound over time. This is how your system builds a tolerance to THC and caffeine, among many other substances.
  • Dependence is what happens when you go through withdrawal symptoms, which can be both physical and emotional. The symptoms may range from mild such as headaches, mood swings, to life-threatening, such as depression, vomiting, heart failure, and lethal overdose.

The good news for CBD users is that it doesn’t cause any of the above. CBD has a good safety profile; it comes with a few mild side effects when you take it regularly, including dry mouth, appetite fluctuation, or slight dizziness if you take high doses of CBD oil.

What Is CBD Reverse Tolerance?

Some studies suggest that CBD can cause reverse tolerance, where less of a compound is needed to achieve the desired effects due to long-term use (4). The studies so far have found that CBD can reduce the activation of CB1 without the need to desensitize the endocannabinoid system. This interaction is particularly important for CBD users because it can reduce the side effects and tolerance-forming potential of other cannabinoids, such as THC.

As we pointed out earlier, providing a definite answer to the tolerance-forming effects of CBD is difficult because there are so many factors at play, and there’s not enough research on humans to provide conclusive results.

CBD Tolerance In A Nutshell

It is common knowledge that people build a tolerance to different substances over time. However, research suggests this isn’t the case with CBD. Some studies have even found CBD oil to induce a reverse tolerance phenomenon, causing the user to need less CBD to experience the same results after regular use.

However, CBD’s unique mechanism of interaction with cannabinoid receptors makes it challenging to study the way it affects tolerance. CBD has over 60 molecular targets, so there’s still much we don’t know about this compound.

If your CBD oil isn’t working, it’s unlikely due to an increased intolerance. Although your threshold may change over time due to factors like age, weight, and metabolism, the problem usually lies in the quality of CBD.

To ensure you’re getting a legitimate product with a proven amount of CBD, make sure you’re buying CBD oil from reputable suppliers. There’s a lot of misinformation surrounding CBD.

We hope this article has helped you clear up any confusion regarding CBD tolerance.

CBD Tolerance: Can you build a tolerance to CBD?

Much like other substances we ingest in our everyday lives, CBD users can build up a tolerance to the cannabinoid compound over time.

So, just as you might need more coffee to get the same energy boost after drinking it every day for a week, you might need to take more CBD to experience the effects to which you are accustomed.

This doesn’t mean that CBD isn’t working anymore or that you’re doing something wrong – it’s just a natural process that happens when our bodies get used to something.

If you are experiencing lessened effects of CBD, or are interested in adjusting your body’s tolerance level, check out this guide covering everything there is to know about CBD tolerance.

The science behind CBD

Cannabidiol (CBD) is one of the most prevalent cannabinoids found in cannabis or hemp plants. Also known as a phytocannabinoid, CBD interacts with our bodies through endocannabinoid system receptors. These receptors are found throughout our entire body, including our brain, organs, and central nervous system.

According to a study published by the National Center for Biotechnology Information (NCBI), CBD activates several receptor types throughout our body: CB1 receptors found in the central nervous system and brain, CB2 receptors found in the peripheral nervous system, enzymes involved with metabolism, muscle and joint function, fertility, and more.

It’s worth noting that while the use of the more well-known cannabinoid THC (tetrahydrocannabinol) also interacts with our endocannabinoid receptors, it does so in a way that causes psychoactive effects or the “high” associated with marijuana use. On the other hand, CBD is non-psychoactive and won’t get you high.

Different types of tolerance

Tolerance can be classified into two different types: metabolic tolerance and functional tolerance.

Metabolic tolerance occurs when the human body loses efficiency in breaking down and metabolizing a substance. For example, if you’re drinking alcohol every day, your liver will eventually become less effective at metabolizing it, resulting in lower blood alcohol concentration.

Functional tolerance is when our body becomes less responsive to the effects of a substance. So, if you’re taking CBD every day, your body may eventually become less responsive to its effects, and you’ll need more of it to experience the same health benefits.

While both types of tolerances could be the culprit for reduced CBD efficacy, it’s more likely that functional tolerance is the culprit for reduced CBD effects because CBD hasn’t been shown to decrease the efficiency of our metabolic and receptor systems. In other words, our bodies just get used to having it in our system – we need more of it because we simply become less sensitive to its presence.

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How can CBD tolerance increase?

CBD tolerance is unavoidable if you engage in regular use of the cannabinoid regularly whether to relieve sore muscles and joints after regular workouts or to help with more serious issues like chronic pain or epilepsy. Just like with any other substance, our bodies will get used to it and eventually require more of the cannabinoid to experience the same effects.

This is because when CBD enters our system, it interacts with enzymes in our liver that are responsible for metabolizing drugs. CBD is a “fat-soluble” compound, which means it’s metabolized differently than other substances like alcohol or caffeine. When we consume CBD, it’s stored in our fatty tissues and liver before being slowly released into our system.

This extended-release is why CBD tends to have long-lasting effects, but it also means that our body has more time to build up a tolerance to the cannabinoid.

Factors that indicate a tolerance to CBD

If you are unsure whether the lessened effects of the CBD you consume for health and wellness are a result of higher tolerance or inferior quality hemp CBD oil extracts, here are some factors to take into account:

  • You find that you need to use more CBD products than before to achieve the desired effects
  • CBD effects aren’t as strong as they used to be
  • It takes longer for CBD effects to kick in

While it’s not uncommon to develop a higher tolerance to CBD over time, it’s important to ensure that the products you’re using are high quality and potent. Inferior quality CBD products might not be giving you the effects you want because they contain a lower concentration of cannabinoids or have not been extracted using the best method.

How to fix a tolerance to CBD

If you’re interested in reducing your tolerance to CBD, there are some things you can do. Changing how you use CBD products is a great place to start, especially if you’ve been using it in the same form for a while.

For example, if you usually take edibles or other CBD gummies , try using a topical CBD product or vape oil instead. You can also switch between full-spectrum, broad-spectrum, and pure CBD isolate products.

If you’re using CBD for medical purposes and have developed a tolerance to it, talk to your doctor about other treatment options. They might be able to recommend a different dosage or form of CBD that would be more effective for you.

It’s also important to take a break from CBD every now and then, especially if you’re using it daily. This will give your body a chance to reset and could help reduce your tolerance to the cannabinoid.

Will I have high CBD tolerance if I have a high THC tolerance?

If you consume marijuana regularly, you might be wondering if your tolerance to THC will affect your tolerance to CBD.

The answer is – not necessarily. While they are both cannabinoids found in cannabis, they interact with our bodies differently. This means that you could have a high tolerance to THC but not CBD, or vice versa.

Furthermore, even though both marijuana and hemp are members of the Cannabis sativa plant family, the CBD content in THC-rich marijuana cannabis plants is much lower than the CBD concentration found in the hemp cannabis plants used to make CBD products in the UK. Therefore, it’s unlikely that your THC tolerance would significantly affect your CBD tolerance.

Why do I feel weird when stopping CBD to reset my tolerance?

Withdrawal symptoms after stopping CBD are infrequent, but they can happen. These side effects are usually mild and include headaches, fatigue, and irritability. Often, this can indicate a CBD dependence, which is different from tolerance to CBD.

A dependence on CBD can occur after long-term use when your body has relied on the cannabinoid for so long that it has grown accustomed to using it, just as it would to caffeine. This means that you will experience mild withdrawal symptoms if you stop using CBD completely, even if you have a high tolerance to it.

Fortunately, it’s easy to reset your sensitivity to CBD and avoid dependence on it if you use the cannabinoid regularly. Simply stop using the cannabinoid for a few days or weeks, then start again with a lower dose than before. You could also swap between full-spectrum CBD oil tinctures and isolate products, as these contain a varying amount of CBD and other hemp compounds.

Does high Endocannabinoid System (ECS) tolerance affect CBD use?

Technically, you can develop a tolerance to any substance that interacts with the endocannabinoid system (ECS). This is because your body naturally produces endocannabinoids – endogenous cannabinoids – which bind to cannabinoid receptors and help regulate various bodily functions.

If you use CBD or THC on a regular basis, your body might start producing less endocannabinoids. This is because it assumes that you’re already getting enough cannabinoids from external sources, so it doesn’t need to produce as many of its own.

Over time, this can decrease sensitivity to cannabinoids, which means you will need to consume more of them to experience the same effects. However, it’s worth noting that this is different from developing a tolerance to CBD or THC specifically.

Natural tolerance factors

Some people may feel like they need more CBD than others to experience the same effects, even if they haven’t been using cannabidiol for a long enough period of time to build a tolerance.

This natural tolerance has less to do with CBD consumption and more with your body’s ability to absorb it. Factors like age, metabolism, weight, height, hydration levels, and genetics are just some of the things that can affect how quickly you feel the effects of cannabidiol.

Time-specific tolerances can also be a factor. For example, you may feel cannabidiol’s effects more in the morning than at night because your body is naturally more receptive to cannabinoids when you first wake up. Or you may feel like you feel the effects more when you don’t eat before taking CBD, as food can also affect how quickly cannabidiol is absorbed into the bloodstream.

Don’t worry, CBD tolerance is normal

While you may feel frustrated that you need more and more CBD to experience the same effects, it’s important to remember that this is perfectly normal. In fact, it’s not just CBD – tolerance can occur with any type of medication or supplement, whether it’s over-the-counter or prescription medications.

The good news is that there are a few things you can do to avoid tolerance build-up, such as taking regular breaks from CBD or using a higher potency product. By understanding how CBD tolerance works, you can make sure you’re using the cannabinoid in the most effective way possible.

You can now buy CBD oil products by clicking here , or read our buyer’s guides to the best CBD oils and best CBD gummies in the UK.

2nd reference, link here

4. Blessed CBD:

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