No, it is not safe to use CBD oil while taking Prednisone simultaneously. CBD can inhibit CYP3A in the body. Read more. Studies have shown that CBD possesses potential therapeutic benefits that may help with some symptoms or conditions where prednisone is indicated. Learn more. CBD may cause fewer side effects than prednisone but can you safely take the two together? We take a look at how these remedies could interact.
Can you safely take CBD oil with Prednisone?
I’ve heard that CBD can interact with many drugs. Are there interactions with Prednisone and CBD oil?
Joel Taylor (Thursday, August 12, 2021):
Both CBD oil and Prednisone are inhibitors of the cytochrome P450 enzyme CYP3A, which means that taking both of them together would result in them having to compete for metabolism. What this means is that the interactions with CBD oil and Prednisone could be dangerous, potentially leading to increased side effects from both. If you are on Prednisone or any other medication, you should talk to your doctor before deciding to try CBD oil as well. Additionally, give it a few hours in between doses to minimize adverse reactions as much as possible.
Osasere Okunloye (Thursday, August 12, 2021):
Studies show that CBD can interact with Prednisone by inhibiting the same enzyme (Cytochrome P450 enzyme CYP3A) as prednisone, and using both of them together may decrease glucocorticoid clearance and increase side effects of Prednisone. Before taking CBD with prednisone or any other medication, you should seek professional advice from a doctor. Reply Follow Share Avik Das Wednesday, January 12, 2022 No, it is not safe to use CBD oil while taking Prednisone simultaneously. CBD can inhibit CYP3A in the body, but Prednisone is also known to inhibit CYP3A in the body. Therefore, using them together might give good results in glucose clearance, but facing systemic side effects is inevitable. It is always best to consult a doctor before using CBD oil with Prednisone.
What Are Some Benefits Of Taking CBD Oil?
CBD oil interacts with your Endocannabinoid system to help control your physiological responses. Taking CBD oil can help you de-stress, and relax, such as via Cannabotech’s Relax drops and Beauty Sleep drops.
CBD oil can also help relax your muscles after a workout, try Unwind Tablets.
CBD Oil and Prednisone – August 2022
Does CBD interact with prednisone, and if so, are there risks that should cause concern?
Prednisone is a prescription drug used to provide relief for inflamed areas of the body. It is also indicated to treat conditions, such as inflammation (swelling), severe allergies, arthritis , asthma, eye or vision problems, blood or bone marrow problems, and stomach or bowel problems (1 ) .
Moreover, doctors prescribe prednisone to help patients with lupus, skin conditions, endocrine problems, kidney problems, ulcerative colitis, adrenal problems, and flare-ups of multiple sclerosis.
Prednisone is a corticosteroid, or a cortisone-like medicine or steroid. This drug works on the immune system to help relieve swelling, redness, itching, and allergic reactions.
However, this medicine may cause changes in mood or behavior for some patients. Symptoms to watch for include depression, trouble with sleeping , a false or unusual sense of well-being, mood swings, and personality changes while taking this medicine (2 ) .
Can CBD Be Taken With Prednisone?
Taking CBD along with prednisone could either decrease the effects of cannabidiol or increase the amount of prednisone entering the bloodstream.
Whenever one takes CBD or any medicine, it passes through the digestive system to the liver, where an enzymatic pathway, called the cytochrome P450 (CYP450) family of enzymes, metabolizes or breaks down the substance ingested.
Liver enzymes CYP450 process about 60% of all medications. One of these, CYP3A4, metabolizes prednisone to make it available to the body (3 ) .
Studies have demonstrated that CBD strongly inhibits the activity of CYP3A4 liver enzymes (4 ) .
Meanwhile, prednisone is a weak inducer of CYP3A4 (5 ) . Still, prednisone may increase how quickly the liver breaks down CBD when they are taken in combination.
In particular, the effects of taking CBD along with prednisone could either decrease the effects of cannabidiol or increase the amount of prednisone entering the bloodstream.
The increased prednisone concentration can amplify the drug’s many side effects and raise the risk of severe symptoms, such as dizziness or fainting, blurred vision, irregular or pounding heartbeat, increased thirst or urination, irritability, and unusual tiredness or weakness (6 ) .
Thus, medical experts advise those taking CBD and prednisone to be cautious with this combination (7 ) .
Can CBD Replace Prednisone?
N o study explicitly says CBD can be used in place of prednisone. However, studies have shown that CBD possesses many potential therapeutic benefits that may help with some symptoms or conditions for which prednisone is indicated.
Prednisone is sometimes prescribed for bone marrow problems , which is important for the health of blood cells . Meanwhile, studies have shown that CBD promotes the structural health of bones .
The effect of CBD on bones was also demonstrated by a 2015 study that investigated the properties of cannabidiol concerning bone-related conditions. Data showed that CBD led to an improvement in fracture healing (8 ) .
Like prednisone, CBD can help with skin conditions. A study published in the journal Trends in Pharmacological Sciences has suggested the existence of a functiona l endocannabinoid system (ECS) in the skin and implicated it in various biological processes (9 ) .
CBD impacts the TRPV-1 and GPR55 receptors (10 ) . Both receptors are found in the skin and play a role in pain signaling and inflammation.
CBD has also been shown to help with mood swings, depression, dizziness, and sleeping difficulty, which may be the side effects from taking prednisone.
A study published in the Journal of Psychopharmacology found that CBD may decrease anxiety levels in individuals with a social anxiety disorder (SAD).
Results indicated that, relative to placebo, CBD was associated with significantly decreased subjective anxiety (11 ) .
In another study, results showed that CBD could theoretically induce rapid-acting antidepressant-like effects and enhance neurotransmission (12 ) . Neurotransmission is the process of communication between nerve cells.
In a 2019 study published in The Permanente Journal , sleep and anxiety scores were measured in human subjects, and the findings showed that CBD could hold benefits for anxiety-related disorders (13 ) .
Meanwhile, CBD’s antiemetic properties, which prevent nausea and vomiting, are incredibly helpful.
A 2014 review from the European Journal of Pharmacology established the potential of cannabis to limit or prevent nausea and vomiting from a wide range of causes (14 ) .
More importantly, the powerful anti-inflammatory properties of CBD could help with some of the same disorders that prednisone treats.
CBD’s anti-inflammatory characteristics have been shown in several human and animal studies, like that of a 2014 study published in the Journal of Clinical Investigation and a 2012 research conducted by authors from the Department of Pathology, School of Veterinary Medicine in the University of São Paulo, Brazil (15 ) .
Other studies have demonstrated that the anti-inflammatory and immunosuppressive actions of CBD may be of use in treating rheumatoid arthritis and the associated pain (16 ) .
Meanwhile, research published in the Free Radical Biology & Medicine Journal by George Booz of the University of Mississippi Medical Center showed that CBD, which may interact with the endocannabinoid system, is a promising prototype for anti-inflammatory drug development (17 ) .
CBD “is generally well tolerated with a good safety profile,” the World Health Organization (WHO) states in a critical review (18 ) .
Still, it is not clear how much to take or how often a person should use it for any particular problem.
High doses of CBD may also interact with other medications, such as blood thinners, antidepressants, and immune suppressors (19 ) .
Thus, individuals should be cautious when supplementing their existing medications with CBD.
Do not take other pharmaceuticals unless they have been discussed with a medical professional.
More importantly, before using CBD as a remedy for specific symptoms or conditions, consult with a doctor experienced in cannabis use for advice.
Does CBD Oil Interact with Prednisone?
Prednisone is a medication which doctors often prescribe for inflammatory conditions. However, it has limited usefulness due to a range of potential side effects. This has led many patients to seek more natural alternatives, including CBD.
CBD has gained attention in recent years as a potent anti-inflammatory. Furthermore, scientists generally consider CBD to be safe, with a relatively low risk of side effects.
But is it safe to take prednisone and CBD together, or will the two interact and make matters even worse? Here’s all you need to know.
What Is Prednisone?
Prednisone belongs to a drug class known as glucocorticoids. These drugs are sometimes known as corticosteroids, or simply steroids. However, they should not be confused with the anabolic steroids that some athletes use.
How Does Prednisone Help Inflammation?
Prednisone works by mimicking the effects of glucocorticoid hormones that the body naturally produces. The adrenal glands secrete these hormones, and they play a role in various physiological functions. One of these functions is regulating the immune system and the inflammatory response.
Inflammation is a natural and healthy response to injury or infection. It allows the immune system to work more efficiently, enabling it to destroy invading pathogens. As a side effect, this process creates swelling, redness, and pain.
In the short term, this response is helpful as it reminds us to take extra care of ourselves while we heal. However, when inflammation fails to switch off when it should, serious problems can occur.
Chronic inflammation can cause pain, such as arthritis and joint pain. It is also associated with many serious conditions.
Glucocorticoid medications such as prednisone help to turn off inflammation by reducing activity in the immune system. Therefore, they can be used to treat a wide range of different medical conditions.
Some of the conditions for which doctors prescribe prednisone include:
- Skin disorders
- Autoimmune disorders (multiple sclerosis, lupus, etc.)
- Some types of arthritis
However, although prednisone is a useful medication with many indications, it can also cause some very unpleasant side effects.
Prednisone Side Effects
The side effects of prednisone include:
- Indigestion or heartburn
- Mood changes
- Increased risk of infection
When you take it over an extended period, prednisone can also cause more serious issues, including:
- Weight gain
- Glucose intolerance
- High blood pressure
- Increased risk of osteoporosis
- Stunted growth in children
Due to this long list of adverse effects, many people would prefer to replace their prednisone with natural alternatives like CBD. But is CBD effective for inflammation, and is this safe to do? Let’s take a look.
How Does CBD Help with Inflammation?
CBD has become popular in recent years as research highlights its many potential benefits. Probably one of the most well-publicized benefits of CBD oil is its anti-inflammatory effects.
CBD helps inflammation by interacting with the body’s endocannabinoid system (ECS). The ECS is made up of chemicals called endocannabinoids, enzymes, and cell receptors known as cannabinoid receptors.
The two main types of cannabinoid receptor are known as CB1 and CB2. CB1 receptors are mainly associated with the nervous system. CB2 receptors are found throughout the body, but they are concentrated in the immune system.
The ECS has many different functions. It helps to maintain a state of balance within the body, including controlling inflammation, immunity, and pain.
These functions are triggered when endocannabinoids bind to cannabinoid receptors. They fit together, like a lock fits a key to open a door.
Plant cannabinoids like THC have a similar chemical structure to these endocannabinoids. Therefore, they can fit into the same receptors and trigger the same reactions.
CBD is slightly different, though. It does not fit into these receptors directly but alters the way that they bind with other molecules, making them more or less effective.
When you take CBD oil, it influences the way endocannabinoids bind with CB2 receptors in the immune system. This helps to help turn off the inflammatory response.
In this sense, CBD is somewhat similar to prednisone. Both therapies can help to suppress the immune system by interacting with its cells.
However, unlike prednisone, CBD is not known to cause serious side effects. That is not to say that CBD will never cause any side effects at all, though. It’s just that they are unlikely to affect everyone or be especially severe.
Does CBD Interact with Prednisone?
If you suffer from an inflammatory condition and take prednisone, you might be wondering whether you can try CBD too. You might think that CBD is safe since it comes from a plant and causes very few side effects.
But unfortunately, despite its relative safety, CBD does have the potential to interact with other drugs. This means you should be cautious when adding CBD to your existing medication.
When you take CBD (or any medicine), it passes through your digestive system to your liver via the hepatic portal vein. In the liver, an enzymatic pathway called the cytochrome P450 pathway (CYP450) metabolizes CBD.
This process involves several enzymes, including one known as CYP3A4. This is an enzyme which is involved in metabolizing around 25% of all drugs, including CBD and prednisone.
Taking CBD can inhibit the action of CYP3A4. This means that other drugs metabolized by the same enzyme get broken down more slowly. Therefore, CBD can increase the concentration of drugs like prednisone in the body, raising the risk of side effects.
To find out whether your medication interacts with CBD, scientists recommend that you use the ‘grapefruit test.’ Grapefruit and grapefruit juice interact with many of the same drugs that CBD does.
So, if your doctor has told you to avoid grapefruit with your medicine, you should probably avoid CBD, too.
Is It Safe to Take CBD and Prednisone Together?
Since CBD oil can interact with prednisone, making side effects more likely, doctors don’t consider them safe to take together.
Sadly, this is the case for many other medications, too. Although for some people enhancing the effects of their medicine can be helpful, for others, it can be dangerous.
Therefore, if you suffer from an inflammatory condition and want to try CBD, you may need to stop your prednisone first. However, you must do this carefully and under the supervision of your physician.
Here’s what you need to know if you are thinking of making the switch from prednisone to CBD.
Making the Switch from Prednisone to CBD
If you use glucocorticoid medication like prednisone, it is essential that you do not stop taking it suddenly. Stopping this type of medicine without gradually tapering the dose down can result in severe withdrawal symptoms.
Some common prednisone withdrawal symptoms include:
- Extreme tiredness
- Joint pain
- Muscle stiffness
- Muscle tenderness
Therefore, if you want to stop taking your prednisone and try CBD instead, be very cautious. Talk to your physician first and explain why you want to make the change. Hopefully, they will be understanding and tell you how to stop taking your prednisone safely.
You may need to do this very slowly over the course of several days or weeks, so be patient. If your doctor is knowledgeable about CBD, they should be able to tell you when it is safe to start using it. In the meantime, ask about other ways to manage your symptoms, such as through diet or exercise.
Making the switch from prednisone to CBD is a slow process. However, it is essential to do it properly to avoid suffering even more.
Does CBD Oil Interact with Prednisone? Final Thoughts
CBD oil and prednisone are both useful anti-inflammatory treatments. However, the two substances are metabolized by the same enzyme, meaning that they can easily interact.
CBD can increase the likelihood of experiencing prednisone side effects, which is the exact opposite of what you want. Therefore, you should not take the two together unless your physician explicitly tells you to do so.
If you want to make the switch from prednisone to CBD, you should do so with caution. Suddenly stopping your medication can have unpleasant withdrawal effects, so talk to your doctor about doing this safely.
You may want to look into different ways to relieve your symptoms without medication while you make the transition. By finding ways to manage your condition with some simple lifestyle changes, you could make things much easier for yourself.
And finally, remember that CBD can interact with many drugs besides prednisone. Always consult your healthcare provider before taking CBD with any other medication.