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Endourage is a great example of the intersection of the CBD industry with the medical/pharmaceutical sector. Many CBD vendors take a strong stance against ‘Big Pharma’ and even the medical community-at-large, due mostly to a polemic against prescription drugs and the adverse effects they can cause. But this position is a bit nearsighted, as there are a handful of groups in the medical space that are doing some pretty amazing things with CBD.

Endourage looks like one of these groups, with a notable team that has a combination of expertise in the cannabis, medical, pharmaceutical, and tech fields. The company is focused on research and development and believes CBD is the ‘future of alternative treatments.’ Here here!

The Endourage site itself is an awesome resource, with substantial studies and research articles that highlight common cannabidiol applications like CBD for anxiety and pain to the lesser-known CBD for heart disease, asthma, and more.

Endourage has just two products featuring what they call their Complete Spectrum™ CBD oil made from organically grown female hemp flowers and processed with ‘proprietary extraction techniques.’ They claim it boasts uber-rich cannabinoid and terpene profiles and is third-party tested for contaminants.

We have a feeling these claims by Endourage check out. But they’ll need to publicly confirm their extraction method(s) and the geographic source of their hemp for the Quality Badge. And as of now, you can only access lab tests after the fact with a QR code, making the Safety Badge a no-go as well.

The Endourage catalog includes CBD oil drops and a CBD topical. The former is suspended in organic MCT oil and comes in concentrations ranging from 150mg to 2400mg. The latter they call the Complete Spectrum™ Musculoskeletal Cream™, an advance formula for rapid relief. The base of this CBD topical is a substance called Lipoderm. Lipoderm is used in many medical-grade transdermals because it delivers the ‘medicine’ (in this case, CBD) efficiently deep into the skin. However, Lipoderm contains synthetics like phenoxyethanol, methylchloroisothiazolinone, and the ickiest, methylisothiazolinone. Some may consider this a fair trade-off, and it’s up to you; we just always call these ingredients out.

We’d genuinely like to know more about Endourage’s Complete Spectrum™ CBD oil and the processes behind it. Who knows, they may even qualify for the Innovation Badge. We urge the brand to disclose more information, including their safety tests, to gain a higher rating with us and pique the interest of the more knowledgeable CBD consumers.

Bottom Line – Endourage is a great example of the merger between the medical community and the CBD industry. They’ve got promise but need to be more transparent and explicit about their sources, ingredients, and processes.

Endourage Complete Spectrum Oral Mucosal Drops (OMD) in Adults Desiring a Reduction in Ethanol Use

This is the first clinical trial of Endourage OMD 1200 for persons desiring to reduce their alcohol consumption.

Condition or disease Intervention/treatment Phase
Alcohol Drinking Alcohol Use, Unspecified Alcohol Abstinence Alcohol-Related Disorders Dietary Supplement: Endourage 1200 mg OMD ™ Oral Mucosal Drops Dietary Supplement: Isolate Other: Placebo Dietary Supplement: Peppermint Oil, masking flavor Not Applicable

CBD is the second most abundant component of the cannabis plant after tetrahydrocannabinol (THC). Unlike THC, CBD does not get users high, but there is some evidence suggesting that it might have anti-anxiety, anticonvulsant, anti-inflammatory and immune boosting, antioxidant effects.

Currently, the only CBD product approved by the Food and Drug Administration is a prescription oil called Epidiolex (Greenwich Biosciences, Inc. 2018). It is approved to treat two types of epilepsy. Aside from Epidiolex, state laws on the use of CBD vary. While CBD is being studied as a treatment for a wide range of conditions, including Parkinson’s disease, schizophrenia, diabetes, multiple sclerosis and anxiety, and addiction, research supporting the drug’s benefits is still limited.

CBD use carries some risks. Though it is often well-tolerated, CBD can cause side effects, such as dry mouth, diarrhea, reduced appetite, drowsiness, and fatigue. CBD can also interact with other medications you are taking, such as blood thinners.

Another cause for concern is the unreliability of the purity and dosage of CBD in products. A recent study of 84 CBD products bought online showed that more than a quarter of the products contained less CBD than labeled. In addition, THC was found in 18 products. If you plan to use products containing CBD, talk to your primary health care provider.

People take cannabidiol by mouth for anxiety, bipolar disorder, a muscle disorder called dystonia, seizures, multiple sclerosis, Parkinson’s disease, and schizophrenia.

Cannabidiol is possibly safe when taken by mouth and appropriately in adults. Cannabidiol doses of up to 300 mg daily have been used safely for up to 6 months. Higher doses of 1200-1500 mg daily have been used safely for up to 4 weeks. Cannabidiol sprays used under the tongue have been used in doses of 2.5 mg for up to 2 weeks.

This is a 112-day, double-blind, placebo-controlled clinical trial evaluating the safety and efficacy of Endourage 1200 mg Complete Spectrum Oral Mucosal Drops (OMD ™). A total of 32 study participants will be enrolled.

Placebo (Hemp seed oil and peppermint flavoring)

Isolate (CBD no terpenes Hemp seed oil [slightly lower concentration of CBD ratio])

Endourage OMD (Full flower extract with a 1:1 ratio of cannabis terpenes, Hemp seed oil and peppermint flavoring)

The isolate formulation contains 0% cannabinoids (CBD 0.00%; CBDa 0.00%; detla 9 THC 0.00%; THCa 0.00%).

Total CBD = CBD + (CBD-A * 0.877). Total THC = THCA-A * 0.877 + Delta 9 THC, ND =

Mentha piperita Leaf /Stem Oil; Physical state: Liquid. Color: Colorless to pale yellow; Characteristic peppermint odor; Not dangerous goods.

  • Peppermint Oil
  • Peppermint Oil, Natural

The isolate formulation contains 0% cannabinoids (CBD 0.00%; CBDa 0.00%; detla 9 THC 0.00%; THCa 0.00%).

Total CBD = CBD + (CBD-A * 0.877). Total THC = THCA-A * 0.877 + Delta 9 THC, ND =

Mentha piperita Leaf /Stem Oil; Physical state: Liquid. Color: Colorless to pale yellow; Characteristic peppermint odor; Not dangerous goods.

  • Peppermint Oil
  • Peppermint Oil, Natural

Placebo OMD Endourage OMD (Full flower extract with a 1:1 ratio of cannabis terpenes, Hemp seed oil and peppermint flavoring)

The CBD/THC ratio of OMD 1200 is 14:1 and the CBD/Terpene ratio is 1:1. Each ¼ dropper contains 10.2 mg of CBD and 0.7 mg of THC. The total % THC is 0.28%. These ratios indicate that the product will not cause euphoria.

  • OMD-1200
  • OMD 1200
  • Endourage OMD 1200

Total CBD = CBD + (CBD-A * 0.877). Total THC = THCA-A * 0.877 + Delta 9 THC, ND =

Mentha piperita Leaf /Stem Oil; Physical state: Liquid. Color: Colorless to pale yellow; Characteristic peppermint odor; Not dangerous goods.

  • Peppermint Oil
  • Peppermint Oil, Natural

OMD Placebo Endourage OMD (Full flower extract with a 1:1 ratio of cannabis terpenes, Hemp seed oil and peppermint flavoring)

The CBD/THC ratio of OMD 1200 is 14:1 and the CBD/Terpene ratio is 1:1. Each ¼ dropper contains 10.2 mg of CBD and 0.7 mg of THC. The total % THC is 0.28%. These ratios indicate that the product will not cause euphoria.

  • OMD-1200
  • OMD 1200
  • Endourage OMD 1200

Total CBD = CBD + (CBD-A * 0.877). Total THC = THCA-A * 0.877 + Delta 9 THC, ND =

Mentha piperita Leaf /Stem Oil; Physical state: Liquid. Color: Colorless to pale yellow; Characteristic peppermint odor; Not dangerous goods.

  • Peppermint Oil
  • Peppermint Oil, Natural
    Anxiety scores [ Time Frame: 112 days (4-months) ]

Generalized Anxiety Disorder (GAD-7), measure for anxiety. Baseline scores will be compared to scores at end of study across arms. Change in anxiety scores from baseline to end of study will be measured. Range from 0-4 for minimal; 5-9 mild; 10-14 moderate; 15-21 severe. Changes will be compared across arms. Increased scores will indicate that study product was not effective in decreasing symptoms measured (anxiety).

Patient Health Questionnaire (PHQ-9), measure for depression. Change in depression scores from baseline to end of study.

Total Score for Depression Severity will be compared across arms from baseline to end of study at 112-days.

Score ranges from:

1-4 Minimal depression; 5-9 Mild depression; 10-14 Moderate depression; 15-19 Moderately severe depression; 20-27 Severe depression. Increased scores indicate that study product is not effective in decreasing symptoms measured (depression).

The Alcohol Craving Questionnaire Short Form (ACQ-SF-R) will be compared from baseline to end of study.

Changes in craving score will be measured in each arm of study. Scores from 1-7 (strongly disagree to strongly agree) is measured across 12 items and 4 sub-scales ([1] compulsivity, [2] expectancy, [3] purposefulness, and [4] emotionality).

The sum of the raw scores for each factor will be calculated and compared from baseline to the end of study across arms.

Increased scores indicate that study product is not effective in reducing cravings for alcohol.

    To determine CBDs impact on anxiety, depression, and alcohol craving that trigger desires to consume alcohol versus abstain. [ Time Frame: 112 days (4-months) ]

Daily diary of symptom(s), dose(s) of study product and alcohol use will be kept by participants.

Diary entries of symptoms, daily dose of study product and daily alcohol use will be measured and compared across study arms from baseline to end of study.

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information

Ages Eligible for Study: 18 Years and older (Adult, Older Adult)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: Yes
  1. Age 18 years of age or older who can provide informed consent
  2. Ability to read and write in the English language and follow study-related procedures
  3. Ability to have mail/ study drug delivered to an address and/or P.O. Box in the recipient’s name.
  4. If a woman of childbearing age, willing to use a dual method of contraception (barrier and/or hormonal)
  1. Active illicit or non-prescribed drug use
  2. Concomitant use of benzodiazepines
  3. Concomitant use of Antabuse
  4. Documented history and active treatment for seizure disorder
  5. Transaminase elevation
  6. Hepatitis C infection (currently on therapy and/or any transaminitis elevation)
  7. Hepatitis B infection (currently on therapy and/or any transaminitis elevation)
  8. Any form of mental impairment that will/could hinder safe participation in the study
  9. Pregnancy or breast-feeding

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04659278

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